Features– category –

On 11 August 2026 the $101 million XPRIZE Healthspan competition named its 20 Finalist teams, awarding $1 million each to 10 of them. Japan took two of those ten. This is a digest of what every team is actually testing - stacked repurposed drugs, engineered and plant-derived extracellular vesicles, mesenchymal stem cells, follistatin and klotho gene therapy, a galectin-3 antibody, elamipretide, progerinin, and Japanese-cuisine-based lifestyle programmes - what each is meant to do in the body, and how far the evidence actually goes.

[Level 1–3 (Strong–Moderate)] [Lifestyle] [Series: In-Depth Health for Your 50s & 60s] "I want to reduce sugar, but what should I use instead?" — By your 50s and 60s, many people ask themselves this question based on health screening res...

[Level 1-2 (Strongest-Strong)] [Diet] [Strongly recommended] "You can eat as much salt as you want; if you drink enough water, your kidneys will flush it all out." "Salt restriction is unnecessary — eat more, actually." Such claims come ...

[Level 1 (Strongest)] [Diet] [Strongly recommended] "Sea salt and rock salt contain minerals, so they're healthy." "Refined salt is bad." "Natural salt is fine in larger amounts." You hear these claims constantly. But here's the conclusi...

[Level 1-2 (Strongest-Strong)] [Diet] [Strongly recommended] "Rice bran oil is the healthy one." "No, olive oil." "Salad oil is outdated." Cooking-oil debates rarely reach a clean conclusion — but the evidence base has clear tiers. Here ...

[Level 1 (Strongest)] [Diet] [Strongly recommended] "Dark green and yellow vegetables are good for you, but cabbage, lettuce, and bean sprouts are nutritionally thin — eating them barely counts." Have you heard this? Half of it is right;...

May 10, 2026: University of Rochester team transferred the naked mole rat HMW-HA synthase gene (HAS2) to mice — median lifespan +4.4%, reduced cancer, improved healthspan. Human translation 10-20 years away. Today's longevity basics remain unchanged.

Dopamine 250%, brown fat, immune boost — does cold plunging deliver any of this? Mood and alertness Level 2; metabolism and lifespan Level 3-4; counterproductive for hypertrophy.

Bryan Johnson reportedly spends $2M/year on anti-aging. The Blueprint core (sleep, exercise, diet) sits at Level 1 and is worth borrowing; the experimental edges remain Level 3–4. A respectful, evidence-grounded audit.

STEP-1: 14.9% weight loss. SURMOUNT-1: 22.5%. SELECT: 20% CV event reduction. GLP-1 drugs are a real revolution — but rebound, muscle loss, monthly cost, and DIY-market risks are equally real.

EFSA cleared NMN at up to 300 mg/day as safe in May 2026. That is not the same as proving it works. An independent, ad-free audit of the human evidence at Levels 1-4.

[Special Feature] XPRIZE Healthspan — Where 40 Teams Stand in the Race for $100 Million Highlights of this feature The XPRIZE Healthspan is the largest-ever competition in aging research, with a total prize pool of $101 million (approxim...