evidage

On 11 August 2026 the $101 million XPRIZE Healthspan competition named its 20 Finalist teams, awarding $1 million each to 10 of them. Japan took two of those ten. This is a digest of what every team is actually testing - stacked repurposed drugs, engineered and plant-derived extracellular vesicles, mesenchymal stem cells, follistatin and klotho gene therapy, a galectin-3 antibody, elamipretide, progerinin, and Japanese-cuisine-based lifestyle programmes - what each is meant to do in the body, and how far the evidence actually goes.

Creatine Supplementation: Scientific Evidence, Safety & Optimal Dosing【Complete Guide for Adults 50s-60s・2025 Edition】 Overview: Creatine supplementation has strong evidence for improving muscle strength and preventing age-related...

[Level 1–3 (Strong–Moderate)] [Lifestyle] [Series: In-Depth Health for Your 50s & 60s] "I want to reduce sugar, but what should I use instead?" — By your 50s and 60s, many people ask themselves this question based on health screening res...

[Level 1-2 (Strongest-Strong)] [Medical] [Series: Serious Reads for Mature Adults] ⚠️ Please read before proceedingThis article is for informational and educational purposes only. It is not medical advice, diagnosis, or treatment. Decisi...

[Level 1-2 (Strongest-Strong)] [Diet] [Strongly recommended] "You can eat as much salt as you want; if you drink enough water, your kidneys will flush it all out." "Salt restriction is unnecessary — eat more, actually." Such claims come ...

[Level 1 (Strongest)] [Diet] [Strongly recommended] "Sea salt and rock salt contain minerals, so they're healthy." "Refined salt is bad." "Natural salt is fine in larger amounts." You hear these claims constantly. But here's the conclusi...

[Level 1-2 (Strongest-Strong)] [Diet] [Strongly recommended] "Rice bran oil is the healthy one." "No, olive oil." "Salad oil is outdated." Cooking-oil debates rarely reach a clean conclusion — but the evidence base has clear tiers. Here ...

[Level 1 (Strongest)] [Diet] [Strongly recommended] "Dark green and yellow vegetables are good for you, but cabbage, lettuce, and bean sprouts are nutritionally thin — eating them barely counts." Have you heard this? Half of it is right;...

May 10, 2026: University of Rochester team transferred the naked mole rat HMW-HA synthase gene (HAS2) to mice — median lifespan +4.4%, reduced cancer, improved healthspan. Human translation 10-20 years away. Today's longevity basics remain unchanged.

May 2026 ACS Nutrition Science study: daily grape consumption changes human skin gene expression and reduces UV-induced oxidative stress. Resveratrol + polyphenols work at the skin level. Eat with the skin — whole food beats supplements.

April 1, 2026: U.S. FDA approves orforglipron, the first oral GLP-1 obesity drug with no water or food restrictions. ATTAIN-1 trial: -12.4% weight loss. Hidden Japan story: compound licensed from Chugai for $50M in 2018.

Through 2026, prospective studies establish microplastics (MNPs) as a cardiovascular risk factor: patients with MNPs in carotid plaques had 4.5x higher 3-year risk of heart attack, stroke, or death (NEJM 2024). Mechanisms: endothelial dysfunction + chronic inflammation + thrombosis. Major sources (bottled water, plastic containers, teabags, indoor dust) and 7 realistic actions you can take today.